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Article

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL.

Leukemia - 1 Jul 2023

Bryant Dean, Smith Lindsay, Rogers-Broadway Karly Rai, Karydis Laura, Woo Jeongmin, Blunt Matthew D, Forconi Francesco, Stevenson Freda K, Goodnow Christopher, Russell Amanda, Humburg Peter, Packham Graham, Steele Andrew J, Strefford Jonathan C

Abstract excerpt

Chronic lymphocytic leukaemia (CLL) cells can express unmutated (U-CLL) or mutated (M-CLL) immunoglobulin heavy chain (IGHV) genes with differing clinical behaviours, variable B cell receptor (BCR) signalling capacity and distinct transcriptional profiles. As it remains unclear how these differences reflect the tumour cells' innate pre/post germinal centre origin or their BCR signalling competence, we applied...

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PMID: 37169950
DOI: 10.1038/s41375-023-01918-9
PMCID: PMC10317834

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