microRNAome expression in chronic lymphocytic leukemia: comparison with normal B-cell subsets and correlations with prognostic and clinical parameters.

doi:10.1158/1078-0432.CCR-13-2497

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Article

microRNAome expression in chronic lymphocytic leukemia: comparison with normal B-cell subsets and correlations with prognostic and clinical parameters.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2014

Negrini Massimo, Cutrona Giovanna, Bassi Cristian, Fabris Sonia, Zagatti Barbara, Colombo Monica, Ferracin Manuela, D'Abundo Lucilla, Saccenti Elena, Matis Serena, Lionetti Marta, Agnelli Luca, Gentile Massimo, Recchia Anna Grazia, Bossio Sabrina, Reverberi Daniele, Rigolin Gianmatteo, Calin George A, Sabbioni Silvia, Russo Giandomenico, Tassone Pierfrancesco, Morabito Fortunato, Ferrarini Manlio, Neri Antonino

Abstract excerpt

PURPOSE: Despite its indolent nature, chronic lymphocytic leukemia (CLL) remains an incurable disease. To establish the potential pathogenic role of miRNAs, the identification of deregulated miRNAs in CLL is crucial. EXPERIMENTAL DESIGN: We analyzed the expression of 723 mature miRNAs in 217 early-stage CLL cases and in various different normal B-cell subpopulations from tonsils and peripheral blood. RESULTS: Our...

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PMID: 24916701
DOI: 10.1158/1078-0432.CCR-13-2497

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