Article
Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia.
Genome research - 1 Feb 2014
Ferreira Pedro G, Jares Pedro, Rico Daniel, Gómez-López Gonzalo, Martínez-Trillos Alejandra, Villamor Neus, Ecker Simone, González-Pérez Abel, Knowles David G, Monlong Jean, Johnson Rory, Quesada Victor, Djebali Sarah, Papasaikas Panagiotis, López-Guerra Mónica, Colomer Dolors, Royo Cristina, Cazorla Maite, Pinyol Magda, Clot Guillem, Aymerich Marta, Rozman Maria, Kulis Marta, Tamborero David, Gouin Anaïs, Blanc Julie, Gut Marta, Gut Ivo, Puente Xose S, Pisano David G, Martin-Subero José Ignacio, López-Bigas Nuria, López-Guillermo Armando, Valencia Alfonso, López-Otín Carlos, Campo Elías, Guigó Roderic
Abstract excerpt
Chronic lymphocytic leukemia (CLL) has heterogeneous clinical and biological behavior. Whole-genome and -exome sequencing has contributed to the characterization of the mutational spectrum of the disease, but the underlying transcriptional profile is still poorly understood. We have performed deep RNA sequencing in different subpopulations of normal B-lymphocytes and CLL cells from a cohort of 98 patients, and...
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