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Article

Molecular pathogenesis of CLL and its evolution.

International journal of hematology - 1 Mar 2015

Rodríguez David, Bretones Gabriel, Arango Javier R, Valdespino Víctor, Campo Elías, Quesada Víctor, López-Otín Carlos

Abstract excerpt

In spite of being the most prevalent adult leukemia in Western countries, the molecular mechanisms driving the establishment and progression of chronic lymphocytic leukemia (CLL) remain largely unknown. In recent years, the use of next-generation sequencing techniques has uncovered new and, in some cases, unexpected driver genes with prognostic and therapeutic value. The mutational landscape of CLL is...

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Chromosome Aberrations
Clonal Evolution
DNA Methylation
Epigenesis, Genetic
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Lymphocytic, Chronic, B-Cell

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PMID: 25630433
DOI: 10.1007/s12185-015-1733-0

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