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Article

Molecular pathogenesis of chronic lymphocytic leukemia.

The Journal of clinical investigation - 1 Oct 2012

Gaidano Gianluca, Foà Robin, Dalla-Favera Riccardo

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Here, we highlight important genetic alterations that contribute to tumorigenesis, clinical progression, and chemorefractoriness of CLL. All CLLs share a common gene expression profile that suggests derivation from antigen-experienced B cells, a model supported by frequent B cell receptor repertoire skewing and stereotypy. Many CLL patients...

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Share to Antigens
Share to Genes, Immunoglobulin
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Leukemia, Experimental

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Somatic Hypermutation, Immunoglobulin

Share to Transferases

Source

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Identifiers

PMID: 23023714
DOI: 10.1172/JCI64101
PMCID: PMC3461921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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