Article

Systems Biology Analysis of DLK1-DIO3 Imprinted microRNAs Cluster in Chronic Lymphocytic Leukemia

2026-06-23

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is a biologically heterogeneous B-cell malignancy in which B-cell receptor signaling, microenvironmental interactions, genomic lesions, and epigenetic deregulation cooperate to shape disease behavior. The imprinted DLK1-DIO3 locus at chromosome 14q32 contains the largest human miRNA cluster and has been implicated in cancer-related regulatory networks; however, its systems-level...

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Literature Corpus work: e9bee0d2-218e-546d-80fe-bcd17a1b5035
DOI: 10.20944/preprints202606.1709.v1

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