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Article

Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance.

Seminars in oncology - 1 Apr 2006

Calin George Adrian, Croce Carlo Maria

Abstract excerpt

Chronic lymphocytic leukemia (CLL), the most frequent leukemia in adults in the Western world, is characterized by predominantly nondividing malignant CD5+ B cells overexpressing the anti-apoptotic Bcl2 protein. Significant familial aggregation with largely unknown mode of inheritance has been demonstrated. Until recently little else was known regarding the events leading to CLL initiation and progression. New...

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Identifiers

PMID: 16616063
DOI: 10.1053/j.seminoncol.2006.01.010

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