Paradigms for mechanical signal transduction in the intestinal epithelium. Category: molecular, cell, and developmental biology.

Abstract excerpt

Diverse physical forces including deformation or strain, pressure, and shear stress affect the intestinal mucosa during normal function, and mucosal biology is altered in pathological states in which these forces alter. Taken together with evidence in other tissues and cell types that physical forces can affect cell biology, this has led to the hypothesis that repetitively applied physical forces can initiate...

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