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Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers

2025-01-29

Abstract excerpt

<title>Abstract</title> <p>Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis, and cancer risk, with symptoms often being exacerbated in women during pregnancy. Here, we show that these IBD hallmarks can be replicated using human Organ Chips lined by IBD patient-derived colon epithelial cells inter...

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Literature Corpus work: 92cb9d27-d89f-5d34-a779-9e3302e0847c
DOI: 10.21203/rs.3.rs-5627712/v1

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