Article

Mechanical stretch regulates inflammatory signaling in human smooth muscle cells

2025-10-30

Abstract excerpt

<h4>Aims</h4> During atherosclerosis progression, vascular smooth muscle cells (SMCs) undergo phenotypic modulation from a contractile state to alternative modulated and proliferative states. Similar transitions occur in vitro , likely due to loss of physiological cues such as specific extracellular matrix (ECM) components and mechanical forces. Here, we investigated how defined ECM substrates and stretch condit...

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Literature Corpus work: 361f5d06-287c-5db2-80d1-9e1159639499
DOI: 10.1101/2025.10.29.685276

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