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Article

Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.

Scientific reports - 24 Oct 2016

Rothdiener Miriam, Hegemann Miriam, Uynuk-Ool Tatiana, Walters Brandan, Papugy Piruntha, Nguyen Phong, Claus Valentin, Seeger Tanja, Stoeckle Ulrich, Boehme Karen A, Aicher Wilhelm K, Stegemann Jan P, Hart Melanie L, Kurz Bodo, Klein Gerd, Rolauffs Bernd

Abstract excerpt

Using matrix elasticity and cyclic stretch have been investigated for inducing mesenchymal stromal cell (MSC) differentiation towards the smooth muscle cell (SMC) lineage but not in combination. We hypothesized that combining lineage-specific stiffness with cyclic stretch would result in a significantly increased expression of SMC markers, compared to non-stretched controls. First, we generated dense collagen...

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Identifiers

PMID: 27775041
DOI: 10.1038/srep35840
PMCID: PMC5075785

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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