Article

Passenger DNA alterations reduce cancer fitness in cell culture and mouse models

2015-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Genomic instability causes cancers to acquire hundreds to thousands of mutations and chromosomal alterations during their somatic evolution. Most of these mutations and alterations are termed passengers because they do not confer cancer phenotypes. Evolutionary simulations and cancer genomic studies suggested that mildly-deleterious passengers accumulate, collectively slow cancer progression, re...

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Identifiers and source

Literature Corpus work: 6296d789-1f98-5e99-9dee-67599c9139fc
DOI: 10.1101/026302

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