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Article

The Damaging Effect of Passenger Mutations on Cancer Progression.

Cancer research - 15 Sept 2017

McFarland Christopher D, Yaglom Julia A, Wojtkowiak Jonathan W, Scott Jacob G, Morse David L, Sherman Michael Y, Mirny Leonid A

Abstract excerpt

Genomic instability and high mutation rates cause cancer to acquire numerous mutations and chromosomal alterations during its somatic evolution; most are termed passengers because they do not confer cancer phenotypes. Evolutionary simulations and cancer genomic studies suggest that mildly deleterious passengers accumulate and can collectively slow cancer progression. Clinical data also suggest an association...

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Identifiers

PMID: 28536279
DOI: 10.1158/0008-5472.CAN-15-3283-T
PMCID: PMC5639691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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