Background mutability shapes observed mutational spectrum in cancer and improves driver mutation prediction

Abstract excerpt

Identifying driver mutations in cancer is notoriously difficult. To date, recurrence of a mutation in patients remains one of the most reliable markers of mutation driver status. However, some mutations are more likely to occur than others due to differences in background mutation rates arising from various forms of infidelity of DNA replication and repair machinery, endogenous, and exogenous mutagens. We used can...

Topics

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• Amino Acid Substitution
• Cancer Genomics and Diagnostics
• DNA Mutational Analysis
• Internet
• Mutagenesis
• Mutation
• Neoplasms
• Software

Identifiers and source

Literature Corpus work

18708413-2c7d-5a09-a98b-e49d7e88530e

DOI

10.1101/354506