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Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis

11 Nov 2022

Abstract excerpt

Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is caused by chromosome segregation errors during cell divisions. Evidence is mounting that the probability of specific chromosomes undergoing a segregation error is non-random. In other words, some chromosomes have a higher chance of contributing to aneuploid karyotypes than others. This could have important implications for the...

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PMID: 36428993
DOI: 10.3390/cells11223564

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