Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

29 Sept 2011

Abstract excerpt

Various types of chromosomal aberrations, including numerical (aneuploidy) and structural (e.g., translocations, deletions), are commonly found in human tumors and are linked to tumorigenesis. Aneuploidy is a direct consequence of chromosome segregation errors in mitosis, whereas structural aberrations are caused by improperly repaired DNA breaks. Here, we demonstrate that chromosome segregation errors can also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21960636
DOI: 10.1126/science.1210214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome AberrationsPMID 21960636Read ↗

Unraveling pathologies underlying chromosomal instability in cancers.Semantic proximity Read ↗

Chromosome Abnormalities: New Insights into Their Clinical Significance in CancerSemantic proximity Read ↗

Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and MeiosisSemantic proximity Read ↗

Deregulation of Chromosome Segregation and CancerSemantic proximity Read ↗

Double-checking chromosome segregationSemantic proximity Read ↗

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural AneuploidiesSemantic proximity Read ↗

The spindle checkpoint and chromosomal stability.Semantic proximity Read ↗

New Cell Cycle Inhibitors Target Aneuploidy in Cancer TherapySemantic proximity Read ↗

Quantitative analysis of the frequency of chromosome loss following DSB inductionSemantic proximity Read ↗

Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapySemantic proximity Read ↗

Profiling DNA damage response following mitotic perturbations.Semantic proximity Read ↗

SAC-ing mitotic errors: how the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.