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Article

Orc6 involved in DNA replication, chromosome segregation, and cytokinesis.

Science (New York, N.Y.) - 9 Aug 2002

Prasanth Supriya G, Prasanth Kannanganattu V, Stillman Bruce

Abstract excerpt

Origin recognition complex (ORC) proteins serve as a landing pad for the assembly of a multiprotein prereplicative complex, which is required to initiate DNA replication. During mitosis, the smallest subunit of human ORC, Orc6, localizes to kinetochores and to a reticular-like structure around the cell periphery. As chromosomes segregate during anaphase, the reticular structures align along the plane of cell...

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Identifiers

PMID: 12169736
DOI: 10.1126/science.1072802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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