Article

Heparan sulfate modified proteins affect cellular processes central to neurodegeneration and modulate <i>presenilin</i> function

2024-01-25

Abstract excerpt

<h4>Summary</h4> Mutations in presenilin-1 (PSEN1) are the most common cause of familial, early-onset Alzheimer’s disease (AD), typically producing cognitive deficits in the fourth decade. A variant of APOE, APOE3 Christchurch (APOE3ch) , was found associated with protection from both cognitive decline and Tau accumulation in a 70-year-old bearing the disease-causing PSEN1-E280A mutation. The amino acid change...

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Literature Corpus work: 6288b33c-99ea-5414-88d8-761d9c0add89
DOI: 10.1101/2024.01.23.576895

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