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Article

Heparan Sulfate Structure Affects Autophagy, Lifespan, Responses to Oxidative Stress, and Cell Degeneration in Drosophila parkin Mutants.

G3 (Bethesda, Md.) - 7 Jan 2020

Reynolds-Peterson Claire, Xu Jie, Zhao Na, Cruse Casey, Yonel Brandon, Trasorras Claire, Toyoda Hidenao, Kinoshita-Toyoda Akiko, Dobson Jennifer, Schultheis Nicholas, Jiang Mei, Selleck Scott

Abstract excerpt

Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded proteins and damaged organelles, a critical mechanism for cellular repair. Earlier work demonstrated that heparan sulfate proteoglycans, an abundant class of carbohydrate-modified proteins found on cell surfaces and in the extracellular matrix, suppress basal...

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Identifiers

PMID: 31672849
DOI: 10.1534/g3.119.400730
PMCID: PMC6945019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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