Article

Neuronal <i>Ndst1</i> depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

2023-06-20

Abstract excerpt

Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a major extracellular matrix component. HS facilitates fibril formation in vitro , yet how HS impacts fibrillar plaque growth within the brain is unclear. Here we found that prion-bound HS chains are highly sulfated, and that the sulfation is essential for HS accelerating prion...

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Literature Corpus work: 514bad10-2d42-52ba-926c-35594d0a251a
DOI: 10.1101/2023.06.19.545528

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