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The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy

15 Feb 2024

Abstract excerpt

The host defence responses play vital roles in viral infection and are regulated by complex interactive networks. The host immune system recognizes viral pathogens through the interaction of pattern-recognition receptors (PRRs) with pathogen-associated molecular patterns (PAMPs). As a PRR mainly in the cytoplasm, cyclic GMP-AMP synthase (cGAS) senses and binds virus DNA and subsequently activates stimulator of...

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PMID: 38426093
DOI: 10.3389/fimmu.2024.1352479

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