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HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer

2019-07-02

Abstract excerpt

Defects in transcriptional regulators of pancreatic exocrine differentiation have been implicated in pancreatic tumorigenesis, but the molecular mechanisms are poorly understood. The locus encoding the transcription factor HNF1A harbors susceptibility variants for pancreatic ductal adenocarcinoma (PDAC), while KDM6A , encoding the histone demethylase UTX, carries somatic mutations in PDAC. Here, we show that panc...

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Identifiers and source

Literature Corpus work
6266390e-a274-517a-b37e-049b5a580d8e
DOI
10.1101/690552
Open publication

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HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancerDOI 10.1101/690552
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