Article
HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer.
The EMBO journal - 4 May 2020
Kalisz Mark, Bernardo Edgar, Beucher Anthony, Maestro Miguel Angel, Del Pozo Natalia, Millán Irene, Haeberle Lena, Schlensog Martin, Safi Sami Alexander, Knoefel Wolfram Trudo, Grau Vanessa, de Vas Matías, Shpargel Karl B, Vaquero Eva, Magnuson Terry, Ortega Sagrario, Esposito Irene, Real Francisco X, Ferrer Jorge
Abstract excerpt
Defects in transcriptional regulators of pancreatic exocrine differentiation have been implicated in pancreatic tumorigenesis, but the molecular mechanisms are poorly understood. The locus encoding the transcription factor HNF1A harbors susceptibility variants for pancreatic ductal adenocarcinoma (PDAC), while KDM6A, encoding Lysine-specific demethylase 6A, carries somatic mutations in PDAC. Here, we show that...
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