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Article

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

3 Aug 2018

Abstract excerpt

The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a human PCSC-enriched gene signature, we identified the transcription factor HNF1A as a putative central regulator of PCSC function. Levels of HNF1A and its target genes were found to be elevated in PCSCs and tumorspheres, and depletion of HNF1A...

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PMID: 30074477
DOI: 10.7554/elife.33947

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