Article

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 on Intracellular Trafficking, Autophagy, and Apoptosis

2023-07-24

Abstract excerpt

<h4>ABSTRACT</h4> The open reading frame 3a (ORF3a) is an accessory transmembrane protein that is important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (YxxΦ; where x is any amino acid and Φ is a hydrophobic amino acid with a bulky -R group). They have been implicated in the trafficking of membrane proteins to the cell plasma membrane and...

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Literature Corpus work: a461e60b-92aa-568b-9b6d-f6ae3e44fab0
DOI: 10.1101/2023.07.24.550379

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