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SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle

30 Nov 2023

Abstract excerpt

Coronavirus replication is associated with the remodeling of cellular membranes, resulting in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified as a putative portal for viral RNA. However, the exact components and the structure of the SARS-CoV-2 DMV pore remain to be determined. Here, we investigate the structure of the DMV pore by in situ cryo-electron tomography combined with...

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PMID: 38036567
DOI: 10.1038/s41467-023-43666-5

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