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The Accessory Protein ORF3a Hijacks CLCC1 Chloride Channel to Cause ER Dysfunction in Beta-coronavirus Pathogenesis

2024-12-16

Abstract excerpt

<title>Abstract</title> <p>The endoplasmic reticulum (ER) homeostasis is crucial for host cells and is influenced by beta-coronaviruses upon invasion. However, the mechanisms by which viral proteins interact with ER-resident host factors to modulate ER functions and morphology remain poorly understood. The accessory protein ORF3a of SARS-CoV-2 plays a pivotal role in viral pathogenesis and modulating host immune...

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Literature Corpus work
2f9eeb05-7e3b-57ed-a6b0-c9c80779563f
DOI
10.21203/rs.3.rs-5241039/v1
Open publication

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