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Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles

17 Jan 2017

Abstract excerpt

Hepatitis E virus (HEV) is the leading cause of enterically transmitted viral hepatitis globally. Of HEV's three ORFs, the function of ORF3 has remained elusive. Here, we demonstrate that via homophilic interactions ORF3 forms multimeric complexes associated with intracellular endoplasmic reticulum (ER)-derived membranes. HEV ORF3 shares several structural features with class I viroporins, and the function of HEV...

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PMID: 28096411
DOI: 10.1073/pnas.1614955114

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