<i>Nfat1</i> regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation

Abstract excerpt

The development of disease-modifying pharmacologic therapy for osteoarthritis (OA) currently faces major obstacles largely because the regulatory mechanisms for the function of adult articular chondrocytes remain unclear. We previously demonstrated that lack of Nfat1, one of the nuclear factor of activated T cells (NFAT) transcription factors, causes OA-like changes in adult mice. This study aimed to identify...

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