Article
Epigenetic mechanisms and non-coding RNAs in osteoarthritis.
Current rheumatology reports - 1 Sept 2013
Barter Matt J, Young David A
Abstract excerpt
Osteoarthritis (OA) is a disease typified by the loss of cartilage, the normal integrity of which is maintained by the resident cell, the chondrocyte. Alterations in chondrocyte gene expression with age, injury, loading or predisposing genetics, underpin OA cartilage loss. Cell- and tissue-specific gene expression is determined by epigenetic mechanisms, including DNA methylation, chromatin modifications and...
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