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Article

Epigenetics in osteoarthritis and its implication for future therapeutics

15 Feb 2013

Abstract excerpt

INTRODUCTION: Changes occurring in the chondrocyte gene that control articular cartilage are important for the onset and progression of osteoarthritis (OA). However, actual development of the disease may be also controlled by changes in epigenome. AREAS COVERED: Topics include the association of the three components of epigenetic modification, i.e., DNA methylation, histone modification, and microRNA expression,...

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PMID: 23410522
DOI: 10.1517/14712598.2013.764410

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