Article

Genome-wide DNA methylation and multi-omics study of human chondrocyte ontogeny and an epigenetic clock analysis of adult chondrocytes

2021-08-02

Abstract excerpt

Articular chondrocytes undergo functional changes and their regenerative potential declines with age. Although the molecular mechanisms guiding articular cartilage aging is poorly understood, DNA methylation is known to play a mechanistic role in aging. However, our understanding of DNA methylation in chondrocyte development across human ontogeny is limited. To better understand DNA methylome changes, methylation...

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Literature Corpus work: ac87fa82-cfb3-5289-af9a-51fc2a86c7c9
DOI: 10.1101/2021.08.02.454544

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