Article

The proofreading mechanism of the human leading strand DNA polymerase ϵ holoenzyme

2025-04-12

Abstract excerpt

The eukaryotic leading strand DNA polymerase epsilon is a dual function enzyme with a proofreading exonuclease site located 40 angstroms from the DNA synthesizing polymerase site. Errors in Pol epsilon proofreading can cause various mutations, including C to G transversions, the most prevalent mutation in cancers and genetic diseases. Pol epsilon interacts with all three subunits of the PCNA ring to assemble a fun...

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Literature Corpus work: 6252aa41-3525-5f44-ab4e-aa17c15148d9
DOI: 10.1101/2025.04.11.648458

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