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Article

DNA replication fidelity.

Annual review of biochemistry - 1 Jan 2000

Kunkel T A, Bebenek K

Abstract excerpt

DNA replication fidelity is a key determinant of genome stability and is central to the evolution of species and to the origins of human diseases. Here we review our current understanding of replication fidelity, with emphasis on structural and biochemical studies of DNA polymerases that provide new insights into the importance of hydrogen bonding, base pair geometry, and substrate-induced conformational changes...

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Identifiers

PMID: 10966467
DOI: 10.1146/annurev.biochem.69.1.497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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