Article
The high fidelity and unique error signature of human DNA polymerase epsilon.
Nucleic acids research - 1 Mar 2011
Korona Dagmara A, Lecompte Kimberly G, Pursell Zachary F
Abstract excerpt
Bulk replicative DNA synthesis in eukaryotes is highly accurate and efficient, primarily because of two DNA polymerases (Pols): Pols δ and ε. The high fidelity of these enzymes is due to their intrinsic base selectivity and proofreading exonuclease activity which, when coupled with post-replication mismatch repair, helps to maintain human mutation rates at less than one mutation per genome duplication. Conditions...
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