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Structural basis for pegRNA-guided reverse transcription by a prime editor

29 May 2024

Abstract excerpt

Abstract The prime editor system composed of Streptococcus pyogenes Cas9 nickase (nSpCas9) and engineered Moloney murine leukaemia virus reverse transcriptase (M-MLV RT) collaborates with a prime editing guide RNA (pegRNA) to facilitate a wide variety of precise genome edits in living cells 1 . However, owing to a lack of structural information, the molecular mechanism of pegRNA-guided reverse transcription by...

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PMID: 38811740
DOI: 10.1038/s41586-024-07497-8

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