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Article

Polymerase dynamics at the eukaryotic DNA replication fork.

The Journal of biological chemistry - 13 Feb 2009

Burgers Peter M J

Abstract excerpt

This review discusses recent insights in the roles of DNA polymerases (Pol) delta and epsilon in eukaryotic DNA replication. A growing body of evidence specifies Pol epsilon as the leading strand DNA polymerase and Pol delta as the lagging strand polymerase during undisturbed DNA replication. New evidence supporting this model comes from the use of polymerase mutants that show an asymmetric mutator phenotype for...

Topics

Animals
DNA
DNA Helicases
DNA Polymerase II
DNA Polymerase III
DNA Replication
Eukaryotic Cells
Flap Endonucleases
Humans
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18835809
DOI: 10.1074/jbc.R800062200
PMCID: PMC2640984

Genes

FEN1

Provenance

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