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Article

Nucleotide variation in histone H2BL drives crossalk of histone modification and promotes tumour cell proliferation by upregulating c-Myc.

Life sciences - 15 Apr 2021

Zhang Lei, Zhang Wei, Sun Jin, Liu Kui-Nan, Gan Zhi-Xue, Liu Yu-Zhou, Chang Jian-Feng, Yang Xiao-Mei, Sun Feng

Abstract excerpt

Gene mutations play important roles in tumour development. In this study, we identified a functional histone H2B mutation H2BL-T11C, causing an amino acid variation from Leu to Pro (L3P, H2BL-L3P). Cells overexpressing H2BL-L3P showed stronger proliferation, colony formation, tumourigenic abilities, and a different cell cycle distribution. Meanwhile, the c-Myc expression was elevated as evident by RNA-seq. We...

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PMID: 33515561
DOI: 10.1016/j.lfs.2021.119127

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