Article

RUVBL1 and RUVBL2 are druggable MYCN regulators in neuroblastoma

2024-10-04

Abstract excerpt

<h4>ABSTRACT</h4> High-risk neuroblastoma is characterized by MYCN amplification and high MYCN or MYC gene expression. These patients have a poor prognosis and there is an urgent need for more effective drugs. While strategies to develop inhibitors that directly target the MYC proteins have remained largely unsuccessful, recent preclinical studies have identified ATR, a key protein of the DNA damage response,...

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Literature Corpus work: 8b34e4e4-85d6-59ff-9b39-bdd870cbc4ff
DOI: 10.1101/2024.10.03.616410

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