Article

Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci

2021-03-26

Abstract excerpt

<h4>ABSTRACT</h4> Chromosomal translocations frequently promote carcinogenesis by producing gain-of-function fusion proteins. Recent studies have identified highly recurrent chromosomal translocations in patients with Endometrial Stromal Sarcomas (ESS) and Ossifying FibroMyxoid Tumors (OFMT) leading to an in-frame fusion of PHF1 (PCL1) to six different subunits of the NuA4/TIP60 complex. While NuA4/TIP60 is a co-...

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Literature Corpus work: 9ff3720c-ec70-50b1-83b8-3e6ef01e8286
DOI: 10.1101/2021.03.26.436670

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