Article

E4F1 and ZNF148 are transcriptional activators of the A57C and wildtype <i>TERT</i> promoter

2023-01-14

Abstract excerpt

<h4>ABSTRACT</h4> Point mutations within the TERT promoter are the most recurrent somatic non-coding mutations identified across different cancer types, including glioblastoma, melanoma, hepatocellular carcinoma, and bladder cancer. They are most abundant at C146T and C124T and rarer at A57C, with the latter originally described as a familial case but subsequently shown also to occur somatically. All three mutat...

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Literature Corpus work: 7b748267-2a47-5d52-b124-149ce0a11a8b
DOI: 10.1101/2023.01.13.523884

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