Article

Deletion mapping of regulatory elements for <i>GATA3</i> reveals a distal T helper 2 cell enhancer involved in allergic diseases

2022-05-25

Abstract excerpt

The GATA3 gene is essential for T cell differentiation and is surrounded by risk variants for immune traits. Interpretation of these variants is challenging because the regulatory landscape of GATA3 is complex with dozens of potential enhancers spread across a large topological associating domain (TAD) and gene expression quantitative trait locus (eQTL) studies provide limited evidence for variant function. Here...

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Literature Corpus work: 6200a4b3-70df-5d76-9a60-7b5434850f67
DOI: 10.1101/2022.05.24.493112

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