Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion mapping of regulatory elements for GATA3 in T cells reveals a distal enhancer involved in allergic diseases.

American journal of human genetics - 6 Apr 2023

Chen Hsiuyi V, Lorenzini Michael H, Lavalle Shanna N, Sajeev Karthyayani, Fonseca Ariana, Fiaux Patrick C, Sen Arko, Luthra Ishika, Ho Aaron J, Chen Aaron R, Guruvayurappan Karthik, O'Connor Carolyn, McVicker Graham

Abstract excerpt

GATA3 is essential for T cell differentiation and is surrounded by genome-wide association study (GWAS) hits for immune traits. Interpretation of these GWAS hits is challenging because gene expression quantitative trait locus (eQTL) studies lack power to detect variants with small effects on gene expression in specific cell types and the genome region containing GATA3 contains dozens of potential regulatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA3 Transcription Factor

Share to Gene Deletion

Share to Hypersensitivity

Share to Quantitative Trait Loci

Share to Regulatory Sequences, Nucleic Acid

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 36990085
DOI: 10.1016/j.ajhg.2023.03.008
PMCID: PMC10119147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion mapping of regulatory elements for GATA3 in T cells reveals a distal enhancer involved in allergic diseases.PMID 36990085Read ↗

Deletion mapping of regulatory elements for <i>GATA3</i> reveals a distal T helper 2 cell enhancer involved in allergic diseasesSemantic proximity Read ↗

A distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation.Semantic proximity Read ↗

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elementsSemantic proximity Read ↗

Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for 12 immune-mediated diseases.Semantic proximity Read ↗

Shared loci but distinct variants underlie genetic architecture of allergic diseasesSemantic proximity Read ↗

Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms.Semantic proximity Read ↗

Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation.Semantic proximity Read ↗

Unveiling GATA3 Signaling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic PotentialSemantic proximity Read ↗

High-resolution promoter interaction analysis implicates genes involved in the activation of Type 3 Innate Lymphoid Cells in autoimmune disease riskSemantic proximity Read ↗

Identification of functional cis-regulatory polymorphisms in the human genome.Semantic proximity Read ↗

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility.Semantic proximity Read ↗

Unveiling GATA3 Signalling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic PotentialSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.