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Article

A distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jul 2024

Kumagai Takashi, Iwata Arifumi, Furuya Hiroki, Kato Kodai, Okabe Atsushi, Toda Yosuke, Kanai Mizuki, Fujimura Lisa, Sakamoto Akemi, Kageyama Takahiro, Tanaka Shigeru, Suto Akira, Hatano Masahiko, Kaneda Atsushi, Nakajima Hiroshi

Abstract excerpt

Asthma is a widespread airway disorder where GATA3-dependent Type-2 helper T (Th2) cells and group 2 innate lymphoid cells (ILC2s) play vital roles. Asthma-associated single nucleotide polymorphisms (SNPs) are enriched in a region located 926-970 kb downstream from GATA3 in the 10p14 (hG900). However, it is unknown how hG900 affects the pathogenesis of allergic airway inflammation. To investigate the roles of the...

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Share to Asthma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

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Source

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Identifiers

PMID: 38923989
DOI: 10.1073/pnas.2320727121
PMCID: PMC11228505

Genes

GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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