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Article

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites.

PLoS pathogens - 1 Mar 2018

Rocamora Frances, Zhu Lei, Liong Kek Yee, Dondorp Arjen, Miotto Olivo, Mok Sachel, Bozdech Zbynek

Abstract excerpt

Due to their remarkable parasitocidal activity, artemisinins represent the key components of first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy of artemisinin-based drugs jeopardizes global efforts to control and ultimately eradicate the disease. To better understand the resistance phenotype, artemisinin-resistant parasite lines were derived from two clones of the 3D7...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29538461
DOI: 10.1371/journal.ppat.1006930
PMCID: PMC5868857

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