Article

High-Ammonia Microenvironment Promotes Stemness and Metastatic Potential in Hepatocellular Carcinoma Through Metabolic Reprogramming

2024-12-02

Abstract excerpt

<title>Abstract</title> <p>Background Hepatocellular carcinoma (HCC) is a prevalent and aggressive form of liver cancer, characterized by frequent recurrence and metastasis, which remain significant obstacles to effective treatment. Ammonia accumulates in the tumor microenvironment of HCC due to dysfunction in the urea cycle, but the detailed impact of ammonia on HCC cells remains insufficiently understood. Meth...

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Literature Corpus work: 61e7859e-2235-589c-abfd-3f7c0e7e3064
DOI: 10.21203/rs.3.rs-5429577/v1

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