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Article

Acid-base Homeostasis and Implications to the Phenotypic Behaviors of Cancer.

Genomics, proteomics & bioinformatics - 1 Dec 2023

Zhou Yi, Chang Wennan, Lu Xiaoyu, Wang Jin, Zhang Chi, Xu Ying

Abstract excerpt

Acid-base homeostasis is a fundamental property of living cells, and its persistent disruption in human cells can lead to a wide range of diseases. In this study, we conducted a computational modeling analysis of transcriptomic data of 4750 human tissue samples of 9 cancer types in The Cancer Genome Atlas (TCGA) database. Built on our previous study, we quantitatively estimated the average production rate of OH-...

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Identifiers

PMID: 35787947
DOI: 10.1016/j.gpb.2022.06.003
PMCID: PMC11082410

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