Article

HGF/c-Met Signaling induces Glutamine Metabolism in Head and Neck Squamous Cell Carcinoma via MAPK/ERK-Dependent Induction of GLS-1

2026-01-06

Abstract excerpt

<title>Abstract</title> <p>Background Head and neck squamous cell carcinoma (HNSCC) is a common malignancy characterized by poor survival due to recurrence, metastasis and therapy resistance. In addition to genetic alterations, metabolic reprogramming is a hallmark of HNSCC and contributes to tumor progression and treatment failure. The hepatocyte growth factor (HGF)/c-Met signaling pathway is frequently activat...

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Literature Corpus work: d9fe20f9-65ad-5619-8e5c-280242d30abb
DOI: 10.21203/rs.3.rs-8233600/v1

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