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Multimodal decoding of human liver regeneration

1 May 2024

Abstract excerpt

Abstract The liver has a unique ability to regenerate 1,2 ; however, in the setting of acute liver failure (ALF), this regenerative capacity is often overwhelmed, leaving emergency liver transplantation as the only curative option 3–5 . Here, to advance understanding of human liver regeneration, we use paired single-nucleus RNA sequencing combined with spatial profiling of healthy and ALF explant human livers to...

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PMID: 38693268
DOI: 10.1038/s41586-024-07376-2

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