Article

Investigation of novel therapies for hyperammonemia

2019-01-01

Abstract excerpt

Ammonia is a toxic compound daily produced and consumed during cell metabolism in the body. It is converted to the less toxic substance urea by the urea cycle in the liver. Moreover, the urea cycle operates anatomically and functionally in sequence with the hepatic glutamine synthetase (GS) to detoxify ammonia and both systems are required for ammonia homeostasis. Urea cycle or GS deficiencies and liver diseases l...

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Literature Corpus work: 790bc0d9-708c-5c32-8f84-19d95b0473ae
DOI: 10.21954/ou.ro.00010de4

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